Design and reporting characteristics of clinical trials investigating sedation practices in the paediatric intensive care unit: a scoping review by SCEPTER (Sedation Consortium on Endpoints and Procedures for Treatment, Education and Research).
Jennifer Jooyoung LeeJerri C PriceJennifer GewandterBethea A KleykampKatherine V BiagasMaryam Y NaimDenham WardRobert H DworkinLena S SunPublished in: BMJ open (2021)
There is substantial heterogeneity in methodological approach in clinical trials evaluating sedation in critically ill paediatric patients. These results provide a basis for the design of future clinical trials to improve the quality of trial data and aid in the development of sedation-related clinical guidelines.
Keyphrases
- clinical trial
- intensive care unit
- mechanical ventilation
- phase ii
- phase iii
- end stage renal disease
- healthcare
- emergency department
- study protocol
- quality improvement
- ejection fraction
- primary care
- open label
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- double blind
- single cell
- randomized controlled trial
- patient reported outcomes
- big data
- current status
- adverse drug
- smoking cessation
- replacement therapy