Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.

Toshiki KurosawaDaiki SakoYuma TegaYasuyuki DeboriYumi TomiharaKazunobu AoyamaYoshiyuki KuboNobuyuki AmanoYoshiharu Deguchi

Published in: Pharmaceutical research (2022)

The 3D-BBB system constructed in this study mimics several important characteristics of the human BBB, and is expected to be a useful high-throughput evaluation tool in the development of CNS drugs.

Keyphrases

blood brain barrier
endothelial cells
high glucose
cerebral ischemia
high throughput
induced pluripotent stem cells
pluripotent stem cells
vascular endothelial growth factor
white matter
single cell
drug induced