Methodological and Reporting Quality of Noninferiority Randomized Controlled Trials Comparing Antibiotic Therapies: A Systematic Review.
Anthony D BaiAdam S KomorowskiCarson K L LoPranav TandonXena X LiVaibhav MokashiAnna CvetkovicVanessa R KayAidan FindlaterLaurel LiangMark LoebDominik MertzPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
There is room for improvement in the methodology and reporting of antibiotic noninferiority trials. Quality can be improved across the entire spectrum from investigators, funding agencies, as well as during the peer-review process.There is room for improvement in the methodology and reporting of antibiotic noninferiority trials including justification of noninferiority margin, reporting of intention-to-treat analysis with per-protocol analysis, and having conclusions that are concordant with study results.Clinical Trials Registration PROSPERO registration number CRD42020165040.