Treatment for radiographically active, sputum culture-negative pulmonary tuberculosis: A systematic review and meta-analysis.
Adam Thorburn GrayLiana MacphersonFfion CarlinBianca SossenAlexandra S RichardsSandra V KikRein M G J HoubenPeter MacPhersonMatteo QuartagnoEwelina RogozińskaHanif EsmailPublished in: PloS one (2023)
Multi-drug regimens were associated with significantly reduced risk of progression to TB disease for individuals with radiographically apparent, but culture-negative TB. However, most studies were old, conducted prior to the HIV epidemic and with outdated regimens. New clinical trials are required to identify the optimal treatment approach.
Keyphrases
- pulmonary tuberculosis
- mycobacterium tuberculosis
- clinical trial
- human immunodeficiency virus
- hiv infected
- cystic fibrosis
- antiretroviral therapy
- emergency department
- hiv positive
- magnetic resonance imaging
- randomized controlled trial
- hiv aids
- computed tomography
- replacement therapy
- open label
- south africa
- men who have sex with men
- smoking cessation