GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation.

Marisa J Stachowski-DollMaria PapadakiThomas G MartinWeikang MaHenry M GongStephanie ShaoShi ShenNitha Aima MuntuMohit KumarEdith Perez Jody L Martin Christine S Moravec Sakthivel Sadayappan Lorenzo R SewananThomas IrvingJonathan A Kirk

Published in: Circulation research (2022)

We identified a novel mechanism by which GSK-3β localizes to the myofilament to modulate LDA. Importantly, z-disc GSK-3β levels were reduced in patients with heart failure, indicating z-disc localized GSK-3β is a possible therapeutic target to restore the Frank-Starling mechanism in patients with heart failure.

Keyphrases

pi k akt
signaling pathway
left ventricular
cell proliferation
heart failure