MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity.
Sofia WaissbluthAgustín D MartínezCindel Figueroa-CaresHelmuth A SánchezJuan C MaassPublished in: Acta oto-laryngologica (2023)
To the best of our knowledge, this is the first study demonstrating the presence and localization of MATE1 in the cochlea. OCT2 labeling was seen in pillar cells. Consistently, OHCs and pillar cells uptake Texas Red cisplatin.