Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer.

Nabeela A KhanKonrad H Stopsack Emma H AllottTravis GerkeEdward L GiovannucciLorelei A MucciPhilip W Kantoff

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2019)

These observations further support the hypothesis that intratumoral cholesterol accumulation through higher synthesis and decreased catabolism is a feature of lethal prostate cancer.

Keyphrases

prostate cancer
radical prostatectomy
low density lipoprotein
poor prognosis
machine learning
deep learning
long non coding rna