Whole-exome and whole-genome sequencing of 1064 individuals with type 1 diabetes reveals novel genes for diabetic kidney disease.

Jani K Haukka Anni A Antikainen Erkka Valo Anna Syreeni Erika B ParenteBridget M LinNora FranceschiniAndrzej S KrolewskiJoanne B Cole Per-Henrik Groop Erkka Valonull null

Published in: Diabetologia (2024)

Our sequencing-based meta-analysis revealed multiple genes, variants and regulatory regions that were suggestively associated with DKD. However, as no variant or gene reached genome-wide significance, further studies are needed to validate the findings.

Keyphrases

genome wide
copy number
dna methylation
systematic review
case control
single cell
genome wide identification
transcription factor
type diabetes
meta analyses
gene expression
genome wide analysis
wound healing
randomized controlled trial