Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury.

Xin LiYan QianWanling ShenShiying ZhangHui HanYu ZhangShuangmei LiuShaokun Lv Xiuying Zhang

Published in: Mediators of inflammation (2023)

Overexpression of SET8 alleviated oxidative stress by regulating Keap1/Nrf2/ARE, inhibited astrocyte autophagy levels, and reduced glial scar formation as well as neuronal loss, thereby promoting improved recovery of motor function after SCI. Thus, the SET8/H4K20me1 regulatory function may be a promising cellular therapeutic intervention point after SCI.

Keyphrases

oxidative stress
signaling pathway
spinal cord injury
induced apoptosis
diabetic rats
ischemia reperfusion injury
randomized controlled trial
dna damage
transcription factor
protein protein
pi k akt
endoplasmic reticulum stress
cell death
cell proliferation
neuropathic pain
small molecule
heat shock