Fatty acid synthase mediates high glucose-induced EGFR activation in oral dysplastic keratinocytes.

David J WisniewskiTao MaAbraham Schneider

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)

These novel findings suggest that FASN may act as a key targetable metabolic regulator of glucose-induced EGFR oncogenic signaling in oral potentially malignant disorders.

Keyphrases

high glucose
endothelial cells
small cell lung cancer
epidermal growth factor receptor
fatty acid
tyrosine kinase
diabetic rats
type diabetes
drug induced
oxidative stress
metabolic syndrome
adipose tissue
insulin resistance
wound healing