Enzalutamide plus androgen-deprivation therapy in hormone-sensitive prostate cancer: new perspectives from a current Phase III clinical trial.
Valentina NorzLaura LawaczeckJens BedkeSteffen RauschArnulf StenzlPublished in: Future oncology (London, England) (2020)
Prostate cancer is a major health issue with an incidence of 1,100,000 worldwide. Eventually, 20-40% of curatively treated patients will face a biochemical recurrence. Lately, the treatment options in metastasized hormone sensitive prostate cancer (mHSPC) were rapidly evolving after years of stagnation. Encouraging results in clinical trials of combination treatment of androgen deprivation therapy with either chemotherapy or second-generation hormonal treatment indicate a paradigm shift in this clinical scenario. In the light of this, the current review is focusing on the concept and initial results of the Phase III (ARCHES) trial investigating enzalutamide plus androgen deprivation therapy in mHSPC. Moreover, a comprehensive appraisal of the expanding landscape of systemic therapies for mHSPC is provided.
Keyphrases
- phase iii
- prostate cancer
- clinical trial
- open label
- phase ii
- radical prostatectomy
- double blind
- study protocol
- end stage renal disease
- newly diagnosed
- placebo controlled
- public health
- ejection fraction
- chronic kidney disease
- type diabetes
- randomized controlled trial
- mesenchymal stem cells
- risk factors
- adipose tissue
- locally advanced
- social media
- peritoneal dialysis
- mental health
- single cell
- squamous cell carcinoma
- combination therapy
- health information