Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case-control study from the ASCUS-COL trial.

María Cecilia Agudelo Samuel Agudelo Attila T Lorincz Arianis Tatiana Ramírez Kelly Melisa Castañeda Isabel C Garcés-Palacio Arnold H Zea Chandrika J Piyathilake Gloria Inéz Sánchez Vásquez

Published in: European journal of nutrition (2023)

High methylation and deficient folate independently increased the risk of CIN3+ while deficient folate combined with high methylation was associated with a substantially elevated risk of CIN3+.

Keyphrases

dna methylation
genome wide
gene expression
clinical trial
study protocol
randomized controlled trial
copy number
wild type
smoking cessation