A case report of loss of thyroid transcription factor 1 expression in lung adenocarcinoma EBUS FNA.
Hitesh MathewRos Bartle-JonesPublished in: Diagnostic cytopathology (2024)
We present a case report of a 76-year-old male with a histologically confirmed KRAS mutated, thyroid transcription factor 1 (TTF1) positive, grade 1, mucinous adenocarcinoma with cytologically difficult to interpret lymph node metastasis showing loss of TTF1 expression and overlapping features with goblet cell hyperplasia. The case highlights the importance of molecular testing in aiding diagnosis and guiding treatment of non-small cell lung carcinomas (NSCLC).
Keyphrases
- transcription factor
- lymph node metastasis
- poor prognosis
- squamous cell carcinoma
- single cell
- cell therapy
- small cell lung cancer
- dna binding
- binding protein
- low grade
- papillary thyroid
- stem cells
- high grade
- long non coding rna
- locally advanced
- replacement therapy
- fine needle aspiration
- ultrasound guided
- rectal cancer
- brain metastases