Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia.
Kelly L WyresTo N T NguyenMargaret M C LamLouise M JuddNguyen van Vinh ChauDavid A B DanceMargaret IpAbhilasha KarkeyClare L LingThyl MiliyaPaul N NewtonNguyen Phu Huong LanAmphone SengduangphachanhPaul TurnerBalaji VeeraraghavanPhat Voong VinhManivanh VongsouvathNicholas R ThomsonStephen BakerKathryn E HoltPublished in: Genome medicine (2020)
K. pneumoniae BSI in South and Southeast Asia are caused by different STs from those predominating in other regions, and with higher frequency of acquired virulence determinants. K. pneumoniae carrying both iuc and AMR genes were also detected at higher rates than have been reported elsewhere. The study demonstrates how genomics-based surveillance-reporting full molecular profiles including STs, AMR, virulence and serotype locus information-can help standardise comparisons between sites and identify regional differences in pathogen populations.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- antimicrobial resistance
- multidrug resistant
- pseudomonas aeruginosa
- public health
- staphylococcus aureus
- biofilm formation
- candida albicans
- genome wide
- adverse drug
- copy number
- health information
- gene expression
- healthcare
- transcription factor
- emergency department
- single molecule
- zika virus