Mendelian randomization analyses identified bioavailable testosterone mediates the effect of sex hormone-binding globulin on prostate cancer.

The results support the potentially protective causal effect of genetically predicted higher SHBG levels against PCa with mediation by the modifiable risk factor, BioT. More research is needed to determine how this possible SHBG-BioT-PCa link works. Targeting SHBG and BioT traits may be a valuable strategy for preventing PCa. This article is protected by copyright. All rights reserved.