The IL-33-ST2-MyD88 axis promotes regulatory T cell proliferation in the murine liver.
Lei XuWei LiXiaofan WangLina ZhangQianqian QiLiyang DongChuan WeiYanan PuYalin LiJifeng ZhuSha ZhouFeng LiuXiaojun ChenChuan SuPublished in: European journal of immunology (2018)
Hepatic Foxp3+ Treg cells are crucial for maintaining local immune homeostasis in the liver. However, the environmental cues required for hepatic Treg cell homeostasis are unclear. In this study, we showed that the IL-33 receptor ST2 was preferentially expressed on Treg cells in the mouse liver, but it was more lowly expressed in the spleen, mesenteric lymph nodes, and blood. More importantly, we found that IL-33 promoted the proliferation of hepatic Treg cells through myeloid differentiation factor MyD88 signaling concomitant with increased cyclin-dependent kinase 4 and cyclin D1 expression. These results suggest that IL-33 is a potential tissue-specific factor controlling Treg cell homeostasis via increased Treg proliferation in the liver.
Keyphrases
- cell cycle arrest
- induced apoptosis
- signaling pathway
- cell proliferation
- lymph node
- cell cycle
- cell death
- pi k akt
- single cell
- cell therapy
- poor prognosis
- endoplasmic reticulum stress
- toll like receptor
- stem cells
- oxidative stress
- acute myeloid leukemia
- risk assessment
- dendritic cells
- bone marrow
- early stage
- protein kinase