ELTD1-An Emerging Silent Actor in Cancer Drama Play.
Ani-Simona SevastreIuliana M BuzatuCarina BaloiAlexandru OpritaAlexandra DragoiLigia G TataranuOana AlexandruStefania TudoracheAnica DricuPublished in: International journal of molecular sciences (2021)
The epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 (ELTD1), is a member of the G-protein coupled receptors (GPCRs) superfamily. Although discovered in 2001, ELTD1 has been investigated only by a few research groups, and important data about its role in normal and tumor cells is still missing. Even though its functions and structure are not yet fully understood, recent studies show that ELTD1 has a role in both physiological and pathological angiogenesis, and it appears to be a very important biomarker and a molecular target in cancer diseases. Upregulation of ELTD1 in malignant cells has been reported, and correlated with poor cancer prognosis. This review article aims to compile the existing data and to discuss the current knowledge on ELTD1 structure and signaling, and its role in physiological and neoplastic conditions.
Keyphrases
- papillary thyroid
- growth factor
- squamous cell
- healthcare
- lymph node metastasis
- electronic health record
- cell proliferation
- squamous cell carcinoma
- poor prognosis
- machine learning
- endothelial cells
- young adults
- oxidative stress
- transcription factor
- mass spectrometry
- deep learning
- amino acid
- high resolution
- binding protein
- endoplasmic reticulum stress
- single molecule
- protein protein