Risk-Related Genes and Associated Signaling Pathways of Gastrointestinal Stromal Tumors.

Fulai GaoJiaqi WangChangjuan LiChangshun XieMiao SuChunyan ZouXiaoli XieDongqiang Zhao

Published in: International journal of general medicine (2022)

gene expression can be used as biomarkers to assess the risk of gastrointestinal stromal tumors whereby expression increases gradually with the increased risk of GIST formation. The genes encode proteins that regulate the division, proliferation and apoptosis of gastrointestinal stromal tumors mainly through PI3K/AKT, MARK, P53, WNT and other signaling pathways.

Keyphrases

signaling pathway
pi k akt
cell cycle arrest
gene expression
cell proliferation
epithelial mesenchymal transition
induced apoptosis
poor prognosis
stem cells
dna methylation
oxidative stress