Interleukin-1 genetic polymorphisms in knee osteoarthritis: What do we know? A meta-analysis and systematic review.

Nicolaas Cyrillus BudhiparamaImelda Lumban-GaolHerawati SudoyoRahadyan MagetsariTri Wibawa

Published in: Journal of orthopaedic surgery (Hong Kong) (2022)

Several IL-1RN alleles and genotypes play a role in knee OA but other genetic variations in the IL-1 region were still conflicting in its association with knee OA.

Keyphrases

knee osteoarthritis
systematic review
meta analyses
genome wide
total knee arthroplasty
gene expression
randomized controlled trial
copy number
dna methylation