Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.

Yi YuLishan JiangJingwen LiLang LeiHouxuan Li

Published in: Journal of periodontology (2021)

HK2-mediated glycolysis promoted RANKL in osteoblasts and enhanced osteoclast differentiation. Targeting glycolysis may provide novel therapeutic methods for reducing alveolar bone loss.

Keyphrases

bone loss
nuclear factor
lps induced
toll like receptor
poor prognosis
signaling pathway
inflammatory response
binding protein
oxidative stress
cancer therapy
pi k akt
drug delivery
newly diagnosed
cell proliferation