Hypoxia Promotes the Expression of ADAM9 by Tubular Epithelial Cells which Enhances TGF-β1 Activation and Promotes Tissue Fibrosis in Lupus Nephritis.

Masataka UmedaKohei KarinoAbhigyan SatyamNobuya YoshidaRyo HisadaRhea BhargavaTheodoros VichosAna Laura KunzlerTakashi IgawaKunihiro IchinoseKenta TorigoeTomoya NishinoTakahiro MaedaCaroline A OwenReza AbdiAtsushi KawakamiGeorge C Tsokos

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Hypoxia promotes the expression of ADAM9 by TECs which is responsible for the development of interstitial fibrosis in LN by enhancing the TGF-β1 activation which promotes fibroblasts to produce collagen and α-SMA.

Keyphrases

poor prognosis
transforming growth factor
endothelial cells
binding protein
long non coding rna
signaling pathway
epithelial mesenchymal transition
extracellular matrix
liver fibrosis