SOX2 mediates cisplatin resistance in small-cell lung cancer with downregulated expression of hsa-miR-340-5p.

Fei CuiZhe-Xue HaoJin LiYa-Lei ZhangXu-Kai LiJian-Xing He

Published in: Molecular genetics & genomic medicine (2020)

We demonstrated that downregulated expression of hsa-miR-340-5p may affect cisplatin resistance by mediating SOX2 expression in SCLC cells, which may provide a potential target for the therapy of chemoresistant SCLCs.

Keyphrases

poor prognosis
small cell lung cancer
stem cells
transcription factor
binding protein
induced apoptosis
long non coding rna
cell death
cell proliferation
signaling pathway
mesenchymal stem cells
brain metastases