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Deregulation of PRDM5 promotes cell proliferation by regulating JAK/STAT signaling pathway through SOCS1 in human lung adenocarcinoma.

Yuanyuan RenYe WangLijiao FangMengchu MaLin GeChao SuLingbiao XinJinyan HeJie YangXin Liu
Published in: Cancer medicine (2022)
Our study suggests that the low expression of PRDM5 promotes the proliferation of lung adenocarcinoma cells by downregulating SOCS1 and then upregulating the JAK2/STAT3 signaling pathway.
Keyphrases
  • signaling pathway
  • induced apoptosis
  • pi k akt
  • cell cycle arrest
  • cell proliferation
  • epithelial mesenchymal transition
  • endothelial cells
  • poor prognosis
  • endoplasmic reticulum stress
  • long non coding rna