Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis.

Yuki TakahashiMasatoshi SaitoHaruo UsudaTsukasa TakahashiShimpei WatanabeTakushi HanitaShinichi SatoYusaku KumagaiShota KoshinamiHideyuki IkedaSean CarterErin L FeeLucy FurfaroSylvain ChemtobJeffrey KeelanDavid OlsonNobuo YaegashiJohn P NewnhamAlan H JobeMatthew W Kemp

Published in: PloS one (2021)

A single dose of rytvela was associated with partial, modest inhibition in the expression of a panel of cytokines/chemokines in fetal tissues undergoing an active inflammatory response.

Keyphrases

inflammatory response
poor prognosis
oxidative stress
lipopolysaccharide induced
low birth weight
gene expression
lps induced
preterm birth
toll like receptor
gestational age
binding protein
preterm infants
immune response