Barbaloin Protects Pentylenetetrazol-Induced Cognitive Deficits in Rodents via Modulation of Neurotransmitters and Inhibition of Oxidative-Free-Radicals-Led Inflammation.
Ahmad Essam AltyarMuhammad AfzalNehmat GhabouraKhalid Saad AlharbiSattam Khulaif AleneziNadeem SayyedImran KazmiPublished in: Pharmaceuticals (Basel, Switzerland) (2024)
The ongoing study has gathered evidence indicating that the injection of barbaloin has resulted in significant improvements in cognitive performance in rats. This is achieved by inhibiting oxidative stress, enhancing the activity of natural antioxidant enzymes, reducing cytokine levels, and increasing the levels of neurotransmitters in the brain. These results were detected in comparison to a PTZ control and can be attributed to the potent anti-inflammatory and antioxidant capabilities of barbaloin, which could be linked to its neuroprotective properties. Barbaloin may potentially increase cognitive decline and boost neuronal survival by altering the expression of
Keyphrases
- oxidative stress
- anti inflammatory
- cognitive decline
- diabetic rats
- mild cognitive impairment
- cerebral ischemia
- dna damage
- induced apoptosis
- poor prognosis
- signaling pathway
- high glucose
- white matter
- drug induced
- multiple sclerosis
- blood brain barrier
- ultrasound guided
- subarachnoid hemorrhage
- functional connectivity
- endothelial cells
- free survival