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Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.

Robert MolokieDonald LavelleMichel GowhariMichael PaciniLani KrauzJohara HassanVinzon IbanezMaria A RuizKwok Peng NgPhilip WoostTomas RadivoyevitchDaisy PacelliSherry FadaMatthew RumpMatthew M HsiehJohn F TisdaleJames JacobbergerMitch A PhelpsJames Douglas EngelSanthosh SarafLewis L HsuVictor GordeukJoseph DeSimoneYogen Saunthararajah
Published in: PLoS medicine (2017)
ClinicalTrials.gov, NCT01685515.
Keyphrases
  • sickle cell disease
  • acute myeloid leukemia
  • dna methylation
  • open label
  • gene expression
  • double blind
  • randomized controlled trial
  • clinical trial