PAX8/PAX8-AS1 DNA methylation levels are associated with objective sleep duration in persons with unexplained hypersomnolence using a deep phenotyping approach.

David T PlanteLigia A PapaleAndy MadridJesse D CookMichael L PrairieReid S Alisch

Published in: Sleep (2021)

This study demonstrates that PAX8/PAX8-AS1 DNA methylation levels are associated with total sleep time in persons with unexplained hypersomnolence. Given prior investigations that have implicated single nucleotide polymorphisms in PAX8/PAX8-AS1 with habitual sleep duration, further research that clarifies the role of DNA methylation levels on these genes in the phenotypic expression of total sleep time is warranted.

Keyphrases

dna methylation
genome wide
gene expression
physical activity
poor prognosis
copy number
depressive symptoms
binding protein
long non coding rna
single cell