Pardinumones A-D: Antibacterial Polyketide-Amino Acid Derivatives from the Mushroom Tricholoma pardinum.
Hui-Xiang YangJin-Tao MaJuan HeZheng-Hui LiRong HuangTao FengJi-Kai LiuPublished in: ACS omega (2021)
Four polyketide-amino acid derivatives, pardinumones A-D (1-4), were isolated from the wild mushroom Tricholoma pardinum. Their structures together with absolute configurations were characterized by means of spectroscopic data analyses, as well as calculated electronic circular dichroism (ECD) and NMR with sorted training set (STS) protocol analysis. Compounds 1-4 exhibited antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli with MIC values in the range of 6.25-50 μg/mL.
Keyphrases
- amino acid
- biofilm formation
- staphylococcus aureus
- escherichia coli
- high resolution
- silver nanoparticles
- magnetic resonance
- randomized controlled trial
- candida albicans
- molecular docking
- electronic health record
- structure activity relationship
- methicillin resistant staphylococcus aureus
- klebsiella pneumoniae
- virtual reality
- deep learning
- mass spectrometry
- essential oil
- data analysis
- cystic fibrosis
- molecular dynamics simulations