pSlug S158 Immunohistochemistry is Useful in Grading Meningioma.

Snail family transcriptional repressor 2 (SNAI2, Slug) is a transcription factor that belong to the Slug/Snail superfamily. Site specific phosphorylation of slug (pSlug S158 ) is detected during the M phase, and thus, this phosphorylated protein is considered a novel marker for detecting mitotic figures. Herein, we investigated whether the detection of mitosis using pSlug S158 expression can be used in the histological grading of meningioma. We performed immunohistochemistry for pSlug S158 and PHH3 in tissue samples of 61 patients with meningioma and examined the association between mitotic counts using pSlug S158 and recurrence-free survival (RFS). The nuclear expression of pSlug S158 was observed in the cell with mitotic figures. Tumor grading based on pSlug S158 was significantly associated with the RFS ( p  < .001). It can be concluded that pSlug S158 is a useful and practical marker to detect mitosis and seems to be reliable for the counting of mitoses in histological grading of meningioma.