Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
Lisa A MarshallSachie MarubayashiAparna JorapurScott JacobsonMikhail ZibinskyOmar RoblesDennis Xiaozhou HuJeffrey J JacksonDeepa PookotJerick SanchezMartin BrovarneyAngela WadsworthDavid ChianDavid WustrowPaul D KassnerGene CutlerBrian WongDirk G BrockstedtOezcan TalayPublished in: Journal for immunotherapy of cancer (2021)
CPI upregulates CCL17 and CCL22 expression in tumors and increases Treg migration into the TME. Pharmacological antagonism of the CCR4 receptor effectively inhibits Treg recruitment and results in enhanced antitumor efficacy either as single agent in CCR4 ligandhigh tumors or in combination with CPIs in CCR4 ligandlow tumors.