Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington's disease.

Tamara VasilkovskaSomaie SalajegheVerdi VanreuselJohan Van AudekerkeMarlies VerschuurenLydiane HirschlerJan WarnkingIsabel PintelonDorian PustinaRoger CachopeLadislav MrzljakIgnacio Muñoz-SanjuanEmmanuel L BarbierWinnok H De VosAnnemie Van der LindenMarleen Verhoye

Published in: Journal of biomedical science (2024)

Our findings reveal early cortical resting-state hyperperfusion and impaired CVR at ages that present motor anomalies in this HD model, suggesting that further characterization of brain perfusion alterations in animal models is warranted as a potential therapeutic target in HD.

Keyphrases

resting state
functional connectivity
mouse model
contrast enhanced
genome wide
magnetic resonance imaging
cross sectional
single cell
magnetic resonance
gene expression
human health
risk assessment