Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated with altered ribosomal protein expression and decreased gentamicin susceptibility.
Justin GreeneRhett A SnyderKatherine L CottenRyan C HuiszoonSangwook ChuRezia Era D BrazaAshley A ChapinJustin M StineWilliam E BentleyReza GhodssiKimberly Michele DavisPublished in: bioRxiv : the preprint server for biology (2024)
, the type-III secretion system (T3SS), is sufficient to lower ribosomal protein expression, since it has been well established that T3SS induction results in growth arrest. We found high levels of T3SS expression promotes slowed growth and antibiotic tolerance, and bacterial cells that survive treatment with a ribosome-targeting antibiotic, gentamicin, have heightened levels of T3SS and lower levels of S10 expression.