Phase II randomised, placebo-controlled, clinical trial of interleukin-1 receptor antagonist in intracerebral haemorrhage: BLOcking the Cytokine IL-1 in ICH (BLOC-ICH).
Adrian R Parry-JonesKatie StockingMary Joan MacLeodBrian ClarkeDavid J WerringKeith W MuirAndy VailPublished in: European stroke journal (2023)
We describe feasibility for delivering anakinra in acute ICH and provide preliminary safety data. We lacked power to test for effects on oedema thus further trials will be required.
Keyphrases
- phase ii
- clinical trial
- placebo controlled
- double blind
- open label
- phase iii
- study protocol
- liver failure
- phase ii study
- respiratory failure
- electronic health record
- randomized controlled trial
- radiation therapy
- aortic dissection
- data analysis
- extracorporeal membrane oxygenation
- mechanical ventilation
- acute respiratory distress syndrome