Expression of hsa-miRNA-15b, -99b, -181a and Their Relationship to Angiogenesis in Renal Cell Carcinoma.
József KirályErzsébet SzabóPetra FodorAnna VassMahua ChoudhuryRudolf GesztelyiCsaba SzászTibor FlaskóNikoletta DobosBarbara ZsebikÁkos József SteliGábor HalmosZsuzsanna SzabóPublished in: Biomedicines (2024)
Significant downregulation of all three miRNAs investigated was observed in tumorous samples compared to adjacent normal kidney tissues. Spearman analysis showed a negative correlation between the expression levels of miRNAs and the pathological grades of the patients. Increased expression of vascular endothelial growth factor-A (VEGF-A) and hypoxia-inducible factor-1α (HIF-1α), a tissue inhibitor of metalloproteinases-1 (TIMP-1), was observed in tumorous samples compared to adjacent normal tissues. Depletion of tissue inhibitors of metalloproteinase-2 (TIMP-2) and metalloproteinase-2 (MMP-2) was detected compared to normal adjacent tissues. The examined miRNAs might function as contributing factors to renal carcinogenesis. However, more prospective studies are warranted to evaluate the potential role of miRNAs in RCC angiogenesis.
Keyphrases
- vascular endothelial growth factor
- endothelial cells
- poor prognosis
- renal cell carcinoma
- gene expression
- end stage renal disease
- binding protein
- ejection fraction
- newly diagnosed
- long non coding rna
- signaling pathway
- peritoneal dialysis
- risk assessment
- patient reported outcomes
- climate change
- high resolution
- atomic force microscopy
- human health
- cell migration