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Different immune contextures underlie tumor site-specific responses to immune checkpoint blockade in esophageal cancer.

Jhe-Cyuan GuoChia-Lang HsuMin-Shu HsiehChia-Chi LinTa-Chen HuangHung-Yang KuoYu-Yun ShaoChih-Hung Hsu
Published in: Thoracic cancer (2023)
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy in advanced esophageal squamous cell carcinoma (ESCC). Heterogeneous responses to ICIs have been reported previously. Here, we describe a patient with advanced ESCC exhibiting a response to durvalumab plus tremelimumab for more than 6 months except primary resistant esophageal tumor. The esophageal tumor had higher regulatory T cells, neutrophils, and mast cells scores estimated by NanoString platform than hepatic tumor. The immunohistochemistry study confirmed higher expression levels of Foxp3, and myeloperoxidase (MPO) in the esophageal tumor. The different immune contextures may underlie the heterogeneous responses to ICI combination in this ESCC patient.
Keyphrases
  • regulatory t cells
  • dendritic cells
  • poor prognosis
  • case report
  • high throughput