Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers.
Shaian TavakolianHossein GoudarziEbrahim FaghihlooPublished in: Infectious agents and cancer (2020)
The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK) activities. Viruses express some onco-proteins which could interfere with CDK and CIKs function, and induce some signals to replicate their genome into host's cells. By reviewing some studies about the function of CDK and CIKs in cells infected with oncoviruses, such as HPV, HTLV, HERV, EBV, KSHV, HBV and HCV, we reviewed the mechanisms of different onco-proteins which could deregulate the cell cycle proteins.
Keyphrases
- cell cycle
- cell proliferation
- induced apoptosis
- cell cycle arrest
- risk factors
- metabolic syndrome
- endothelial cells
- type diabetes
- hepatitis b virus
- risk assessment
- hepatitis c virus
- weight loss
- endoplasmic reticulum stress
- heavy metals
- cell death
- high grade
- physical activity
- weight gain
- air pollution
- liver failure
- pluripotent stem cells
- induced pluripotent stem cells
- childhood cancer
- hiv infected
- disease virus