Tofacitinib and Baricitinib Are Taken up by Different Uptake Mechanisms Determining the Efficacy of Both Drugs in RA.

Jan AmrheinSusanne DryndaLukas SchlattUwe KarstChristoph H LohmannGiuliano CiarimboliJessica Bertrand

Published in: International journal of molecular sciences (2020)

We observed different cellular uptake strategies for Baricitinib and Tofacitinib. Tofacitinib was exported out of healthy cells due to the increased expression of MATE1. This might make Tofacitinib the favourable drug.

Keyphrases

rheumatoid arthritis
ulcerative colitis
disease activity
induced apoptosis
poor prognosis
interstitial lung disease
cell cycle arrest
drug induced
endoplasmic reticulum stress
cell proliferation