Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome.

Quan-Bo ZhangYu-Feng QingCong-Cong YinLi ZhouXian-Shuang LiuQing-Sheng MiJing-Guo Zhou

Published in: Arthritis research & therapy (2018)

Collectively, these observations suggest that miR-146a provides negative feedback regulation of gouty arthritis development and lack of miR-146a enhances gouty arthritis via upregulation of TRAK6, IRAK-1, and the NALP3 inflammasome function.

Keyphrases

cell proliferation
long non coding rna
rheumatoid arthritis
long noncoding rna
poor prognosis
early onset
signaling pathway
high fat diet induced
insulin resistance
drug induced