Targeting ferroptosis as a vulnerability in pulmonary diseases.
Li YangLi-Mian CaoXiao-Ju ZhangBo ChuPublished in: Cell death & disease (2022)
Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events.
Keyphrases
- cell death
- pulmonary hypertension
- drug resistant
- oxidative stress
- multidrug resistant
- chronic obstructive pulmonary disease
- dna damage
- fatty acid
- systemic sclerosis
- transcription factor
- risk assessment
- acinetobacter baumannii
- signaling pathway
- idiopathic pulmonary fibrosis
- weight gain
- combination therapy
- replacement therapy
- pseudomonas aeruginosa
- induced apoptosis
- smoking cessation