Lipid is heterogeneously distributed in muscle and associates with low radiodensity in cancer patients.
Amritpal S BhullarAna Anoveros-BarreraAbha Dunichand-HoedlKaren MartinsDavid BigamRachel G KhadarooTodd McMullenOliver F BatheCharles T PutmanMichael T ClandininVickie E BaracosVera C MazurakPublished in: Journal of cachexia, sarcopenia and muscle (2020)
Repeated measures revealed wide variation in radiodensity of RA muscle, both vertically and horizontally. Low muscle radiodensity reflects high level of TG in patients with cancer. Non-uniform distribution of intramyocellular and extramyocellular lipids was evident using light microscopy. These results warrant investigation of mechanisms resulting in lipid deposition in muscles of cancer patients.