Randomized phase III trial of metabolic imaging-guided dose escalation of radio-chemotherapy in patients with newly diagnosed glioblastoma (SPECTRO GLIO trial).

Anne LaprieGeorges NoelLeonor ChaltielGilles TrucMarie-Pierre SunyachMarie CharissouxNicolas MagnePierre AuberdiacJulian BiauSoléakhéna KenFatima TensaoutiJonathan KhalifaIngrid SidibeFranck-Emmanuel RouxLaure VieillevigneIsabelle CatalaaSergio BoettoUro-Coste EmmanuelleStéphane SupiotValérie BernierThomas FilleronMuriel MounierMuriel PoublancPascale OlivierJean-Pierre DelordElizabeth Cohen-Jonathan-Moyal

Published in: Neuro-oncology (2023)

The additional MRSI-guided irradiation dose totaling 72 Gy was well-tolerated but did not improve OS in newly diagnosed GBM.

Keyphrases

phase iii
newly diagnosed
open label
phase ii
clinical trial
double blind
placebo controlled
high resolution
study protocol
randomized controlled trial
locally advanced
mass spectrometry
radiation therapy
radiation induced
fluorescence imaging
photodynamic therapy