Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.

Emma C AlexanderDuaa FaruqiRobert FarquharAyesha UnadkatKyla Ng YinRebecca HoskynsRachel VarugheseSasha Rose Howard

Published in: European journal of endocrinology (2024)

This systematic review provides convincing evidence of the efficacy of gonadotropins for pubertal induction. However, there remains substantial heterogeneity in treatment choice, dose, duration, and outcomes assessed. Formal guidelines and randomized studies are needed.

Keyphrases

systematic review
meta analyses
double blind
open label
replacement therapy
single cell
placebo controlled
phase iii
randomized controlled trial
skeletal muscle
weight loss