Impact of the methylation classifier and ancillary methods on CNS tumor diagnostics.
Zhichao WuZied AbdullaevSriram VennetiHye-Jung ChungShannon SkarshaugValerie ZgoncCandice PerrySvetlana PackLola SaidkhodjaevaSushma NagarajManoj TyagiVineela GangalapudiKristin ValdezRust TurakulovLiqiang XiMark RaffeldAntonios Papanicolau-SengosKayla O'DonnellMichael NewfordMark R GilbertFelix SahmAbigail K SuwalaAndreas von DeimlingYasin MamatjanShirin KarimiFarshad NassiriGelareh ZadehEytan RuppinMartha QuezadoKenneth D AldapePublished in: Neuro-oncology (2021)
This work assesses the impact of a methylation classifier and additional methods in a consultative practice by defining the proportions with concordant vs. change in diagnosis in a set of diagnostically challenging CNS tumors. We address approaches to low-confidence scores and confounding issues of low tumor purity.