Engineering Multifunctional Polyetheretherketone Implant: Mechanics-adaptability, Biominerialization, Immunoregulation, Antiinfection, Osteointegration and Osteogenesis.

Polyether ether ketone (PEEK) has become one of the most promising polymer implants in bone orthopedics, due to the biocompatibility, good processability and radiation resistance. However, the poor mechanics-adaptability/osteointegration/osteogenesis/antiinfection limit the long-term in vivo applications of PEEK implant. Herein, the multifunctional PEEK implant (PEEK-PDA-BGNs) was constructed through in situ surface deposition of polydopamine-bioactive glass nanoparticles (PDA-BGNs). PEEK-PDA-BGNs exhibited good performance on osteointegration and osteogenesis in vitro and in vivo, due to their multifunctional properties including mechanics-adaptability, biominerialization, immunoregulation, anti-infection and osteoinductive activity. PEEK-PDA-BGNs could show the bone tissue-adaptable mechanic surface, induce the rapid biomineralization (apatite formation) under the simulated body solution. Additionally, PEEK-PDA-BGNs could induce the M2 phenotype polarization of macrophages, reduce the expression of inflammatory factors, promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and improve the osseointegration and osteogenesis ability of PEEK implant. PEEK-PDA-BGNs also showed good photothermal antibacterial activity and can kill 99% of Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA), suggesting their potential antiinfection ability. This work suggests that PDA-BGNs coating probably a facile strategy to construct multifunctional (biomineralization, antibacterial, immunoregulation) implants for bone tissue replacement. This article is protected by copyright. All rights reserved.