Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness.

Alex C H Liu Severine Cathelin Yitong Yang David L Dai Dhanoop Manikoth Ayyathan Mohsen Hosseini Mark D Minden Anne Tierens Steven M Chan

Published in: Cancer research (2022)

A CRISPR knockout screen identifies a mechanism of resistance to IDH inhibitors in AML involving activated STAT5 signaling, suggesting a potential strategy to improve the clinical efficacy of IDH inhibitors.

Keyphrases

low grade
wild type
genome wide
cell proliferation
stem cells
acute myeloid leukemia
crispr cas
epithelial mesenchymal transition
high throughput
gene expression
genome editing
dna methylation
climate change
risk assessment
allogeneic hematopoietic stem cell transplantation
human health