Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter.

Zsolt BagiDieter D BrandnerPhuong LeDavid W McNealXi GongHuijuan DouDavid J FultonAllison BellerThuan NgyuenEric B LarsonThomas J MontineC Dirk Keene Stephen A Back

Published in: Annals of neurology (2019)

Selectively impaired vasodilator function of WM penetrating arterioles in mVBI occurs in association with aberrant differentiation of OPCs in WMI, which supports that myelination disturbances in VCID are related to disrupted maturation of myelinating oligodendrocytes. Ann Neurol 2018;83:142-152.

Keyphrases

white matter
multiple sclerosis
oxidative stress
neural network
neural stem cells