C Dirk Keene (C Keene)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 62

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science (New York, N.Y.)

Nature communications

eLife

University of Washington

University of Minnesota (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Washington Jul 01 2009

United States

Associate Professor :: Pathology

Education History

University of Minnesota Jul 24 1995 - Jun 15 2009

United States

PHD :: Neuroscience

Publications

Juhyuk Park, Ji Wang, Webster Guan, Lars A Gjesteby, Dylan Pollack, Lee Kamentsky, Nicholas B Evans, Jeff Stirman, Xinyi Gu, Chuanxi Zhao, Slayton Marx, Minyoung E Kim, Seo Woo Choi, Michael Snyder, David Chavez, Clover Su-Arcaro, Yuxuan Tian, Chang Sin Park, Qiangge Zhang, Dae Hee Yun, Mira Moukheiber, Guoping Feng, Xiangdong William Yang, C Dirk Keene, Patrick R Hof, Satrajit S Ghosh, Matthew P Frosch, Laura J Brattain, Kwanghun Chung
Integrated platform for multiscale molecular imaging and phenotyping of the human brain. Science (New York, N.Y.) 384 (6701) (2024)
Kian Kalhor, Chien-Ju Chen, Ho Suk Lee, Matthew Cai, Mahsa Nafisi, Richard Que, Carter R Palmer, Yixu Yuan, Yida Zhang, Xuwen Li, Jinghui Song, Amanda Knoten, Blue B Lake, Joseph P Gaut, C Dirk Keene, Ed S Lein, Peter V Kharchenko, Jerold Chun, Sanjay Jain, Jian-Bing Fan, Kun Zhang
Mapping human tissues with highly multiplexed RNA in situ hybridization. Nature communications 15 (1) (2024)
Harshvardhan Gazula, Henry F J Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adria Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Sean I Young, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L MacDonald, C Dirk Keene, Bradley T Hyman, Juan Eugenio Iglesias
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. eLife 12 (2024)
Juhyuk Park, Ji Wang, Webster Guan, Lars A Gjesteby, Dylan Pollack, Lee Kamentsky, Nicholas B Evans, Jeff Stirman, Xinyi Gu, Chuanxi Zhao, Slayton Marx, Minyoung E Kim, Seo Woo Choi, Michael Snyder, David Chavez, Clover Su-Arcaro, Yuxuan Tian, Chang Sin Park, Qiangge Zhang, Dae Hee Yun, Mira Moukheiber, Guoping Feng, Xiangdong William Yang, C Dirk Keene, Patrick R Hof, Satrajit S Ghosh, Matthew P Frosch, Laura J Brattain, Kwanghun Chung
Integrated platform for multiscale molecular imaging and phenotyping of the human brain. Science (New York, N.Y.) 384 (6701) (2024)
Kian Kalhor, Chien-Ju Chen, Ho Suk Lee, Matthew Cai, Mahsa Nafisi, Richard Que, Carter R Palmer, Yixu Yuan, Yida Zhang, Xuwen Li, Jinghui Song, Amanda Knoten, Blue B Lake, Joseph P Gaut, C Dirk Keene, Ed S Lein, Peter V Kharchenko, Jerold Chun, Sanjay Jain, Jian-Bing Fan, Kun Zhang
Mapping human tissues with highly multiplexed RNA in situ hybridization. Nature communications 15 (1) (2024)
Kian Kalhor, Chien-Ju Chen, Ho Suk Lee, Matthew Cai, Mahsa Nafisi, Richard Que, Carter R Palmer, Yixu Yuan, Yida Zhang, Xuwen Li, Jinghui Song, Amanda Knoten, Blue B Lake, Joseph P Gaut, C Dirk Keene, Ed S Lein, Peter V Kharchenko, Jerold Chun, Sanjay Jain, Jian-Bing Fan, Kun Zhang
Mapping human tissues with highly multiplexed RNA in situ hybridization. Nature communications 15 (1) (2024)
Juhyuk Park, Ji Wang, Webster Guan, Lars A Gjesteby, Dylan Pollack, Lee Kamentsky, Nicholas B Evans, Jeff Stirman, Xinyi Gu, Chuanxi Zhao, Slayton Marx, Minyoung E Kim, Seo Woo Choi, Michael Snyder, David Chavez, Clover Su-Arcaro, Yuxuan Tian, Chang Sin Park, Qiangge Zhang, Dae Hee Yun, Mira Moukheiber, Guoping Feng, Xiangdong William Yang, C Dirk Keene, Patrick R Hof, Satrajit S Ghosh, Matthew P Frosch, Laura J Brattain, Kwanghun Chung
Integrated platform for multiscale molecular imaging and phenotyping of the human brain. Science (New York, N.Y.) 384 (6701) (2024)
Orly Lazarov, Ahmed Disouky, Mark Sanborn, Mostafa Mostafa, K Sabitha, Aimee Schantz, Namhee Kim, Szymon Pawlowski, William Honer, David Bennett, Yi Zhou, C Dirk Keene, Mark Maienschein-Cline, Jalees Rehman
A roadmap to human hippocampal neurogenesis in adulthood, aging and AD. Research square (2024)
Harshvardhan Gazula, Henry F J Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adria Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Sean I Young, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L MacDonald, C Dirk Keene, Bradley T Hyman, Juan Eugenio Iglesias
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. eLife 12 (2024)
Harshvardhan Gazula, Henry F J Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adria Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Sean I Young, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L MacDonald, C Dirk Keene, Bradley T Hyman, Juan Eugenio Iglesias
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. eLife 12 (2024)
Kian Kalhor, Chien-Ju Chen, Ho Suk Lee, Matthew Cai, Mahsa Nafisi, Richard Que, Carter R Palmer, Yixu Yuan, Yida Zhang, Xuwen Li, Jinghui Song, Amanda Knoten, Blue B Lake, Joseph P Gaut, C Dirk Keene, Ed S Lein, Peter V Kharchenko, Jerold Chun, Sanjay Jain, Jian-Bing Fan, Kun Zhang
Mapping human tissues with highly multiplexed RNA in situ hybridization. Nature communications 15 (1) (2024)
Kian Kalhor, Chien-Ju Chen, Ho Suk Lee, Matthew Cai, Mahsa Nafisi, Richard Que, Carter R Palmer, Yixu Yuan, Yida Zhang, Xuwen Li, Jinghui Song, Amanda Knoten, Blue B Lake, Joseph P Gaut, C Dirk Keene, Ed S Lein, Peter V Kharchenko, Jerold Chun, Sanjay Jain, Jian-Bing Fan, Kun Zhang
Mapping human tissues with highly multiplexed RNA in situ hybridization. Nature communications 15 (1) (2024)
Orly Lazarov, Ahmed Disouky, Mark Sanborn, Mostafa Mostafa, K Sabitha, Aimee Schantz, Namhee Kim, Szymon Pawlowski, William Honer, David Bennett, Yi Zhou, C Dirk Keene, Mark Maienschein-Cline, Jalees Rehman
A roadmap to human hippocampal neurogenesis in adulthood, aging and AD. Research square (2024)
Orly Lazarov, Ahmed Disouky, Mark Sanborn, Mostafa Mostafa, K Sabitha, Aimee Schantz, Namhee Kim, Szymon Pawlowski, William Honer, David Bennett, Yi Zhou, C Dirk Keene, Mark Maienschein-Cline, Jalees Rehman
A roadmap to human hippocampal neurogenesis in adulthood, aging and AD. Research square (2024)
Kian Kalhor, Chien-Ju Chen, Ho Suk Lee, Matthew Cai, Mahsa Nafisi, Richard Que, Carter R Palmer, Yixu Yuan, Yida Zhang, Xuwen Li, Jinghui Song, Amanda Knoten, Blue B Lake, Joseph P Gaut, C Dirk Keene, Ed S Lein, Peter V Kharchenko, Jerold Chun, Sanjay Jain, Jian-Bing Fan, Kun Zhang
Mapping human tissues with highly multiplexed RNA in situ hybridization. Nature communications 15 (1) (2024)
Orly Lazarov, Ahmed Disouky, Mark Sanborn, Mostafa Mostafa, K Sabitha, Aimee Schantz, Namhee Kim, Szymon Pawlowski, William Honer, David Bennett, Yi Zhou, C Dirk Keene, Mark Maienschein-Cline, Jalees Rehman
A roadmap to human hippocampal neurogenesis in adulthood, aging and AD. Research square (2024)
Hind Bouzid, Julia A Belk, Max Jan, Yanyan Qi, Chloé Sarnowski, Sara Wirth, Lisa Ma, Matthew R Chrostek, Herra Ahmad, Daniel C Nachun, Winnie Yao, null null, Alexa Beiser, Alexander G Bick, Joshua C Bis, Myriam Fornage, William T Longstreth, Oscar L Lopez, Pradeep Natarajan, Bruce M Psaty, Claudia L Satizabal, Joshua S Weinstock, Eric B Larson, Paul K Crane, C Dirk Keene, Sudha Seshadri, Ansuman T Satpathy, Thomas J Montine, Siddhartha Jaiswal
Clonal hematopoiesis is associated with protection from Alzheimer's disease. Nature medicine (2023)
Nikolas L Jorstad, Janet H T Song, David Exposito-Alonso, Hamsini Suresh, Nathan Castro-Pacheco, Fenna M Krienen, Anna Marie Yanny, Jennie Close, Emily Gelfand, Brian R Long, Stephanie C Seeman, Kyle J Travaglini, Soumyadeep Basu, Marc Beaudin, Darren Bertagnolli, Megan Crow, Song-Lin Ding, Jeroen Eggermont, Alexandra Glandon, Jeff Goldy, Katelyn Kiick, Thomas Kroes, Delissa A McMillen, Trangthanh H Pham, Christine Rimorin, Kimberly Siletti, Saroja Somasundaram, Michael Tieu, Amy Torkelson, Guoping Feng, William D Hopkins, Thomas Höllt, C Dirk Keene, Sten Linnarsson, Steven A McCarroll, Boudewijn P F Lelieveldt, Chet C Sherwood, Kimberly A Smith, Christopher A Walsh, Alexander Dobin, Jonathan M Werner, Ed S Lein, Rebecca D Hodge, Trygve E Bakken
Comparative transcriptomics reveals human-specific cortical features. Science (New York, N.Y.) 382 (6667) (2023)
Thomas Chartrand, Rachel Dalley, Jennie Close, Natalia A Goriounova, Brian R Lee, Rusty Mann, Jeremy A Miller, Gábor Molnár, Mukora Alice, Lauren Alfiler, Katherine Baker, Trygve E Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, Krissy Brouner, Tamara Casper, Éva Adrienn Csajbók, Nick Dee, Tom Egdorf, Rachel Enstrom, Anna A Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S Heistek, DiJon Hill, Nikolas L Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela Leon, Brian R Long, Matthew Mallory, Medea McGraw, Delissa A McMillen, Erica J Melief, Norbert Mihut, Lindsay Ng, Julie Nyhus, Gáspár Oláh, Attila Ozsvár, Victoria Omstead, Zoltan Peterfi, Christina Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Marton Rozsa, Augustin Ruiz, Joanna Sandle, Susan M Sunkin, Ildikó Szöts, Michael Tieu, Martin Tóth, Jessica Trinh, Sara Vargas, David Vumbaco, Grace Williams, Julia Wilson, Zizhen Yao, Pál Barzó, Charles Cobbs, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W Gouwens, Benjamin L Grannan, Ryder P Gwinn, Jason S Hauptman, Tim Jarsky, C Dirk Keene, Andrew L Ko, Christof Koch, Jeffrey G Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L Silbergeld, Kimberly A Smith, Staci A Sorensen, Bosiljka Tasic, Jonathan T Ting, Jack Waters, Christiaan P J de Kock, Huibert D Mansvelder, Gabor Tamas, Hongkui Zeng, Brian E Kalmbach, Ed S Lein
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex. Science (New York, N.Y.) 382 (6667) (2023)
Gennifer E Merrihew, Jea Park, Deanna Plubell, Brian C Searle, C Dirk Keene, Eric B Larson, Randell J Bateman, Richard J Perrin, Jasmeer P Chhatwal, Martin R Farlow, Catriona A McLean, Bernardino Ghetti, Kathy L Newell, Matthew P Frosch, Thomas J Montine, Michael J MacCoss
A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease. Scientific data 10 (1) (2023)
Nikolas L Jorstad, Jennie Close, Nelson J Johansen, Anna Marie Yanny, Eliza R Barkan, Kyle J Travaglini, Darren Bertagnolli, Jazmin Campos, Tamara Casper, Kirsten Crichton, Nick Dee, Song-Lin Ding, Emily Gelfand, Jeff Goldy, Daniel Hirschstein, Katelyn Kiick, Matthew Kroll, Michael Kunst, Kanan Lathia, Brian R Long, Naomi X Martin, Delissa A McMillen, Trangthanh H Pham, Christine Rimorin, Augustin Ruiz, Nadiya V Shapovalova, Soraya I Shehata, Kimberly Siletti, Saroja Somasundaram, Josef Sulc, Michael Tieu, Amy Torkelson, Herman Tung, Edward M Callaway, Patrick R Hof, C Dirk Keene, Boaz P Levi, Sten Linnarsson, Partha P Mitra, Kimberly A Smith, Rebecca D Hodge, Trygve E Bakken, Ed S Lein
Transcriptomic cytoarchitecture reveals principles of human neocortex organization. Science (New York, N.Y.) 382 (6667) (2023)
Zhi Huang, Gennifer E Merrihew, Eric B Larson, Jea Park, Deanna L Plubell, Edward J Fox, Kathleen S Montine, Caitlin S Latimer, C Dirk Keene, James Y Zou, Michael J MacCoss, Thomas J Montine
Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. Nature communications 14 (1) (2023)
Mariano Gabitto, Kyle J Travaglini, Jeannelle Ariza, Eitan Kaplan, Brian R Long, Victoria Rachleff, Yi Ding, Joseph Mahoney, Nick Dee, Jeff Goldy, Erica Melief, Krissy Brouner, Jazmin Compos, John Campos, Ambrose Carr, Tamara Casper, Rushil Chakrabarty, Michael Clark, Jonah Cool, Rachel Dalley, Martin Darvas, Tim Dolbeare, Song-Lin Ding, Tom Egdorf, Luke Esposito, Rebecca Ferrer, Rohan Gala, Amanda Gary, Jessica Gloe, Nathan Guilford, Junitta Guzman, Windy Ho, Tim Jarsky, Nelson Johansen, Brian E Kalmbach, Lisa Keene, Sarah Khawand, Mitchell D Kilgore, Amanda Kirkland, Michael Kunst, Brian Lee, Christine Mac Donald, Jocelin Malone, Zoe Maltzer, Naomi Martin, Rachel McCue, Delissa A McMillen, Emma Meyerdierks, Kelly Meyers, Tyler Mollenkopf, Mark Montine, Amber Nolan, Julie Nyhus, Paul Olsen, Maiya Pacleb, Trangthanh H Pham, Christina Pom, Nadia Postupna, Augustin Ruiz, Aimee Schantz, Staci Sorensen, Brian Staats, Matt Sullivan, Susan Sunkin, Carol Thompson, Michael Tieu, Jonathan Ting, Amy Torkelson, Tracy Tran, Nasmil Valera Cuevas, Ming-Qiang Wang, Jack Waters, Angela Wilson, David Haynor, Nicole Gatto, Suman Jayadev, Shoaib Mufti, Lydia Ng, Shubhabrata Mukherjee, Paul Crane, Caitlin Latimer, Boaz P Levi, Kimberly A Smith, Jennie Close, Jeremy A Miller, Rebecca D Hodge, Eric Larson, Thomas Grabowski, Michael J Hawrylycz, C Dirk Keene, Ed S Lein
Integrated multimodal cell atlas of Alzheimer's disease. Research square (2023)
Brian R Lee, Rachel Dalley, Jeremy A Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Mukora Alice, Lindsay Ng, Lauren Alfiler, Katherine Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Éva Adrienn Csajbók, Nicholas Donadio, Stan L W Driessens, Tom Egdorf, Rachel Enstrom, Anna A Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S Heistek, DiJon Hill, Wen-Hsien Hou, Nelson J Johansen, Nikolas L Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela León, Brian R Long, Matthew Mallory, Michelle Maxwell, Medea McGraw, Delissa A McMillen, Erica J Melief, Gábor Molnár, Marty T Mortrud, Dakota Newman, Julie Nyhus, Ximena Opitz-Araya, Attila Ozsvár, Trangthanh H Pham, Christina Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Augustin Ruiz, Susan M Sunkin, Ildikó Szöts, Naz Taskin, Bargavi Thyagarajan, Michael Tieu, Jessica Trinh, Sara Vargas, David Vumbaco, Femke Waleboer, Sarah Walling-Bell, Natalie Weed, Grace Williams, Julia Wilson, Shenqin Yao, Thomas Zhou, Pál Barzó, Trygve E Bakken, Charles Cobbs, Nick Dee, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W Gouwens, Benjamin L Grannan, Ryder P Gwinn, Jason S Hauptman, Rebecca D Hodge, Tim Jarsky, C Dirk Keene, Andrew L Ko, Anders Rosendal Korshoej, Boaz P Levi, Kaare Meier, Jeffrey G Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L Silbergeld, Kimberly A Smith, Jens Christian Hedemann Sørensen, Jack Waters, Hongkui Zeng, Jim Berg, Marco Capogna, Natalia A Goriounova, Brian E Kalmbach, Christiaan P J de Kock, Huibert D Mansvelder, Staci A Sorensen, Gabor Tamas, Ed S Lein, Jonathan T Ting
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex. Science (New York, N.Y.) 382 (6667) (2023)
Nelson J Johansen, Saroja Somasundaram, Kyle J Travaglini, Anna Marie Yanny, Maya Shumyatcher, Tamara Casper, Charles Cobbs, Nick Dee, Richard G Ellenbogen, Manuel Ferreira, Jeff Goldy, Junitta B Guzman, Ryder P Gwinn, Daniel Hirschstein, Nikolas L Jorstad, C Dirk Keene, Andrew L Ko, Boaz P Levi, Jeffrey G Ojemann, Trangthanh H Pham, Nadiya V Shapovalova, Daniel Silbergeld, Josef Sulc, Amy Torkelson, Herman Tung, Kimberly A Smith, Ed S Lein, Trygve E Bakken, Rebecca D Hodge, Jeremy A Miller
Interindividual variation in human cortical cell type abundance and expression. Science (New York, N.Y.) 382 (6667) (2023)
Rachael Ann Batabyal, Ankush Bansal, Laura Reck Cechinel, Kayla Authelet, Madeleine Goldberg, Evan Nadler, C Dirk Keene, Suman Jayadev, Kimiko Domoto-Reilly, Gail Li, Elaine Peskind, Kazue Hashimoto-Torii, Dedra Buchwald, Robert J Freishtat
Adipocyte-Derived Small Extracellular Vesicles from Patients with Alzheimer Disease Carry miRNAs Predicted to Target the CREB Signaling Pathway in Neurons. International journal of molecular sciences 24 (18) (2023)
Katherine E Prater, Kevin J Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L Smith, Kenneth L Chiou, Laura Heath, Shannon E Rose, Jesse Wiley, C Dirk Keene, Ronald Y Kwon, Noah James Snyder-Mackler, Elizabeth E Blue, Benjamin Logsdon, Jessica E Young, Ali Shojaie, Gwenn A Garden, Suman Jayadev
Human microglia show unique transcriptional changes in Alzheimer's disease. Nature aging (2023)
Zhi Huang, Gennifer E Merrihew, Eric B Larson, Jea Park, Deanna L Plubell, Edward J Fox, Kathleen S Montine, Caitlin S Latimer, C Dirk Keene, James Y Zou, Michael J MacCoss, Thomas J Montine
Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. Nature communications 14 (1) (2023)
Wei Tian, Jingtian Zhou, Anna Bartlett, Qiurui Zeng, Hanqing Liu, Rosa Gomez Castanon, Mia Kenworthy, Jordan Altshul, Cynthia Valadon, Andrew I Aldridge, Joseph R Nery, Huaming Chen, Jiaying Xu, Nicholas D Johnson, Jacinta Lucero, Julia K Osteen, Nora Emerson, Jonathan A Rink, Jasper Lee, Yang Eric Li, Kimberly Siletti, Michelle Liem, Naomi Claffey, Carolyn O'Connor, Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya V Shapovalova, Daniel Hirschstein, Song-Lin Ding, Rebecca D Hodge, Boaz P Levi, C Dirk Keene, Sten Linnarsson, Ed S Lein, Bing Ren, M Margarita Behrens, Joseph R Ecker
Single-cell DNA methylation and 3D genome architecture in the human brain. Science (New York, N.Y.) 382 (6667) (2023)
Mean-Hwan Kim, Cristina Radaelli, Elliot R Thomsen, Deja Monet, Thomas Chartrand, Nikolas L Jorstad, Joseph T Mahoney, Michael J Taormina, Brian Long, Katherine Baker, Trygve E Bakken, Luke Campagnola, Tamara Casper, Michael Clark, Nick Dee, Florence D'Orazi, Clare Gamlin, Brian E Kalmbach, Sara Kebede, Brian R Lee, Lindsay Ng, Jessica Trinh, Charles Cobbs, Ryder P Gwinn, C Dirk Keene, Andrew L Ko, Jeffrey G Ojemann, Daniel L Silbergeld, Staci Sorensen, Jim Berg, Kimberly A Smith, Philip R Nicovich, Tim Jarsky, Gabe J Murphy, Hongkui Zeng, Jonathan T Ting, Boaz P Levi, Ed Lein
Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex. eLife 12 (2023)
Kimberly Siletti, Rebecca D Hodge, Alejandro Mossi Albiach, Ka Wai Lee, Song-Lin Ding, Lijuan Hu, Peter Lönnerberg, Trygve E Bakken, Tamara Casper, Michael Clark, Nick Dee, Jessica Gloe, Daniel Hirschstein, Nadiya V Shapovalova, C Dirk Keene, Julie Nyhus, Herman Tung, Anna Marie Yanny, Ernest Arenas, Ed S Lein, Sten Linnarsson
Transcriptomic diversity of cell types across the adult human brain. Science (New York, N.Y.) 382 (6667) (2023)
Farr Niere, Ayse Uneri, Colin J McArdle, Zhiyong Deng, Hailey X Egido-Betancourt, Luisa P Cacheaux, Sanjeev V Namjoshi, William C Taylor, Xin Wang, Samuel H Barth, Cameron Reynoldson, Juan Penaranda, Michael P Stierer, Chelcie F Heaney, Suzanne Craft, C Dirk Keene, Tao Ma, Kimberly F Raab-Graham
Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America 120 (45) (2023)
Yang Eric Li, Sebastian Preissl, Michael Miller, Nicholas D Johnson, Zihan Wang, Henry Jiao, Chenxu Zhu, Zhaoning Wang, Yang Xie, Olivier B Poirion, Colin Kern, António Pinto-Duarte, Wei Tian, Kimberly Siletti, Nora Emerson, Julia Osteen, Jacinta Lucero, Lin Lin, Qian Yang, Quan Zhu, Nathan R Zemke, Sarah Espinoza, Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya V Shapovalova, Daniel Hirschstein, Rebecca D Hodge, Sten Linnarsson, Trygve E Bakken, Boaz P Levi, C Dirk Keene, Jingbo Shang, Ed S Lein, Allen Wang, M Margarita Behrens, Joseph R Ecker, Bing Ren
A comparative atlas of single-cell chromatin accessibility in the human brain. Science (New York, N.Y.) 382 (6667) (2023)
Megha Jhanji, Chintada Nageswara Rao, Jacob C Massey, Marion C Hope, Xueyan Zhou, C Dirk Keene, Tao Ma, Michael D Wyatt, Jason A Stewart, Mathew Sajish
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration. Nature communications 13 (1) (2022)
Carlo Condello, Alison M Maxwell, Erika Castillo, Atsushi Aoyagi, Caroline Graff, Martin Ingelsson, Lars Lannfelt, Thomas D Bird, C Dirk Keene, William W Seeley, Daniel P Perl, Elizabeth Head, Stanley B Prusiner
Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proceedings of the National Academy of Sciences of the United States of America 119 (46) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Luke Campagnola, Stephanie C Seeman, Thomas Chartrand, Lisa Kim, Alex Hoggarth, Clare R Gamlin, Shinya Ito, Jessica Trinh, Pasha A Davoudian, Cristina Radaelli, Mean-Hwan Kim, Travis A Hage, Thomas Braun, Lauren Alfiler, Julia Andrade, Phillip Bohn, Rachel Dalley, Alex Henry, Sara Kebede, Mukora Alice, David Sandman, Grace Williams, Rachael Larsen, Corinne Teeter, Tanya L Daigle, Kyla Berry, Nadezhda I Dotson, Rachel Enstrom, Melissa Gorham, Madison T Hupp, Samuel Dingman Lee, Kiet Ngo, Philip R Nicovich, Lydia Potekhina, Shea Ransford, Amanda Gary, Jeff Goldy, Delissa A McMillen, Trangthanh H Pham, Michael Tieu, La' Akea Siverts, Miranda Walker, Colin Farrell, Martin Schroedter, Clifford R Slaughterbeck, Charles Cobbs, Richard Ellenbogen, Ryder P Gwinn, C Dirk Keene, Andrew L Ko, Jeffrey G Ojemann, Daniel L Silbergeld, Daniel Carey, Tamara Casper, Kirsten Crichton, Michael Clark, Nick Dee, Lauren Ellingwood, Jessica Gloe, Matthew Kroll, Josef Sulc, Herman Tung, Katherine Wadhwani, Krissy Brouner, Tom Egdorf, Michelle Maxwell, Medea McGraw, Christina Alice Pom, Augustin Ruiz, Jasmine Bomben, David Feng, Nika Hejazinia, Shu Shi, Aaron Szafer, Wenjing Yin, John Phillips, Amy Bernard, Luke Esposito, Florence D D'Orazi, Susan M Sunkin, Kimberly A Smith, Bosiljka Tasic, Anton Arkhipov, Staci Sorensen, Ed S Lein, Christof Koch, Gabe Murphy, Hongkui Zeng, Tim Jarsky
Local connectivity and synaptic dynamics in mouse and human neocortex. Science (New York, N.Y.) 375 (6585) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
James H Park, Abdullah H Feroze, Samuel N Emerson, Anca B Mihalas, C Dirk Keene, Patrick J Cimino, Adrian Lopez Garcia de Lomana, Kavya Kannan, Wei-Ju Wu, Serdar Turkarslan, Nitin S Baliga, Anoop P Patel
A single-cell based precision medicine approach using glioblastoma patient-specific models. NPJ precision oncology 6 (1) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Dylan Shea, Elizabeth Colasurdo, Alec Simon Tulloch Smith, Courtnie Paschall, Suman Jayadev, C Dirk Keene, Douglas Galasko, Andrew L Ko, Ge Li, Elaine Peskind, Valerie Daggett
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Thanaphong Phongpreecha, Chandresh R Gajera, Candace C Liu, Kausalia Vijayaragavan, Alan L Chang, Martin Becker, Ramin Fallahzadeh, Rosemary Fernandez, Nadia Postupna, Emily Sherfield, Dmitry Tebaykin, Caitlin S Latimer, Carol A Shively, Thomas C Register, Suzanne Craft, Kathleen S Montine, Edward J Fox, Kathleen L Poston, C Dirk Keene, R Michael Angelo, Sean C Bendall, Nima Aghaeepour, Thomas J Montine
Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE. Science advances 7 (51) (2021)
Jim Berg, Staci A Sorensen, Jonathan T Ting, Jeremy A Miller, Thomas Chartrand, Anatoly Buchin, Trygve E Bakken, Agata Budzillo, Nick Dee, Song-Lin Ding, Nathan W Gouwens, Rebecca D Hodge, Brian E Kalmbach, Changkyu Lee, Brian R Lee, Lauren Alfiler, Katherine Baker, Eliza Barkan, Allison Beller, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, Tamara Casper, Peter Chong, Kirsten Crichton, Rachel Dalley, Rebecca de Frates, Tsega Desta, Samuel Dingman Lee, Florence D'Orazi, Nadezhda Dotson, Tom Egdorf, Rachel Enstrom, Colin Farrell, David Feng, Olivia Fong, Szabina Furdan, Anna A Galakhova, Clare Gamlin, Amanda Gary, Alexandra Glandon, Jeff Goldy, Melissa Gorham, Natalia A Goriounova, Sergey Gratiy, Lucas T Gray, Hong Gu, Kristen Hadley, Nathan Hansen, Tim S Heistek, Alex M Henry, Djai B Heyer, DiJon Hill, Chris Hill, Madison T Hupp, Tim Jarsky, Sara Kebede, Lisa Keene, Lisa Kim, Mean-Hwan Kim, Matthew Kroll, Caitlin Latimer, Boaz P Levi, Katherine E Link, Matthew Mallory, Rusty Mann, Desiree Marshall, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica Melief, Eline J Mertens, Leona Mezei, Norbert Mihut, Stephanie Mok, Gábor Molnár, Alice Mukora, Lindsay Ng, Kiet Ngo, Philip R Nicovich, Julie Nyhus, Gaspar Olah, Aaron Oldre, Victoria Omstead, Attila Ozsvar, Daniel Park, Hanchuan Peng, Trangthanh H Pham, Christina A Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea Ransford, David Reid, Christine Rimorin, Augustin Ruiz, David Sandman, Josef Sulc, Susan M Sunkin, Aaron Szafer, Viktor Szemenyei, Elliot R Thomsen, Michael Tieu, Amy Torkelson, Jessica Trinh, Herman Tung, Wayne Wakeman, Femke Waleboer, Katelyn Ward, René Wilbers, Grace Williams, Zizhen Yao, Jae-Geun Yoon, Costas A Anastassiou, Anton Arkhipov, Pal Barzo, Amy Bernard, Charles Cobbs, Philip C De Witt Hamer, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Ryder P Gwinn, Michael J Hawrylycz, Patrick R Hof, Sander Idema, Allan R Jones, C Dirk Keene, Andrew L Ko, Gabe J Murphy, Lydia Ng, Jeffrey G Ojemann, Anoop P Patel, John W Phillips, Daniel L Silbergeld, Kimberly A Smith, Bosiljka Tasic, Rafael Yuste, Idan Segev, Christiaan P J de Kock, Huibert D Mansvelder, Gabor Tamas, Hongkui Zeng, Christof Koch, Ed S Lein
Human neocortical expansion involves glutamatergic neuron diversification. Nature 598 (7879) (2021)
Trygve E Bakken, Nikolas L Jorstad, Qiwen Hu, Blue B Lake, Wei Tian, Brian E Kalmbach, Megan Crow, Rebecca D Hodge, Fenna M Krienen, Staci A Sorensen, Jeroen Eggermont, Zizhen Yao, Brian D Aevermann, Andrew I Aldridge, Anna Bartlett, Darren Bertagnolli, Tamara Casper, Rosa G Castanon, Kirsten Crichton, Tanya L Daigle, Rachel Dalley, Nick Dee, Nikolai C Dembrow, Dinh Diep, Song-Lin Ding, Weixiu Dong, Rongxin Fang, Stephan Fischer, Melissa Goldman, Jeff Goldy, Lucas T Gray, Brian R Herb, Xiaomeng Hou, Jayaram Kancherla, Matthew Kroll, Kanan Lathia, Baldur van Lew, Yang Eric Li, Christine S Liu, Hanqing Liu, Jacinta D Lucero, Anup A Mahurkar, Delissa McMillen, Jeremy A Miller, Marmar Moussa, Joseph R Nery, Philip R Nicovich, Sheng-Yong Niu, Joshua Orvis, Julia K Osteen, Scott Owen, Carter R Palmer, Trangthanh H Pham, Nongluk Plongthongkum, Olivier Poirion, Nora M Reed, Christine Rimorin, Angeline Rivkin, William J Romanow, Adriana E Sedeño-Cortés, Kimberly Siletti, Saroja Somasundaram, Josef Sulc, Michael Tieu, Amy Torkelson, Herman Tung, Xinxin Wang, Fangming Xie, Anna Marie Yanny, Renee Zhang, Seth A Ament, M Margarita Behrens, Hector Corrada Bravo, Jerold Chun, Alexander Dobin, Jesse Gillis, Ronna Hertzano, Patrick R Hof, Thomas Höllt, Gregory D Horwitz, C Dirk Keene, Peter V Kharchenko, Andrew L Ko, Boudewijn P F Lelieveldt, Chongyuan Luo, Eran A Mukamel, António Pinto-Duarte, Sebastian Preissl, Aviv Regev, Bing Ren, Richard H Scheuermann, Kimberly A Smith, William J Spain, Owen R White, Christof Koch, Michael J Hawrylycz, Bosiljka Tasic, Evan Z Macosko, Steven A McCarroll, Jonathan T Ting, Hongkui Zeng, Kun Zhang, Guoping Feng, Joseph R Ecker, Sten Linnarsson, Ed S Lein
Comparative cellular analysis of motor cortex in human, marmoset and mouse. Nature 598 (7879) (2021)
Brett M Frye, Suzanne Craft, Caitlin S Latimer, C Dirk Keene, Thomas J Montine, Thomas C Register, Miranda E Orr, Kylie Kavanagh, Shannon L Macauley, Carol A Shively
Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus). American journal of primatology 83 (11) (2021)
Steven J Wu, Scott N Furlan, Anca B Mihalas, Hatice S Kaya-Okur, Abdullah H Feroze, Samuel N Emerson, Ye Zheng, Kalee Carson, Patrick J Cimino, C Dirk Keene, Jay F Sarthy, Raphaël Gottardo, Kami Ahmad, Steven Henikoff, Anoop P Patel
Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression. Nature biotechnology 39 (7) (2021)
Fang Zhang, Mary Gannon, Yunjia Chen, Shun Yan, Sixue Zhang, Wendy Feng, Jiahui Tao, Bingdong Sha, Zhenghui Liu, Takashi Saito, Takaomi C Saido, C Dirk Keene, Kai Jiao, Erik D Roberson, Huaxi Xu, Qin Wang
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science translational medicine 12 (526) (2021)
Julie C Lauterborn, Pietro Scaduto, Conor D Cox, Anton Schulmann, Gary Lynch, Christine M Gall, C Dirk Keene, Agenor Limon
Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease. Nature communications 12 (1) (2021)
Zhourui Wu, Chun Chen, Seong Su Kang, Xia Liu, Xiaohuan Gu, Shan Ping Yu, C Dirk Keene, Liming Cheng, Keqiang Ye
Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 118 (25) (2021)
Atsushi Aoyagi, Carlo Condello, Jan Stöhr, Weizhou Yue, Brianna M Rivera, Joanne C Lee, Amanda L Woerman, Glenda M Halliday, Sjoerd G van Duinen, Martin Ingelsson, Lars Lannfelt, Caroline Graff, Thomas D Bird, C Dirk Keene, William W Seeley, William F DeGrado, Stanley B Prusiner
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain. Science translational medicine 11 (490) (2020)
Jeanna M Wheeler, Pamela McMillan, Timothy J Strovas, Nicole F Liachko, Alexandre Amlie-Wolf, Rebecca L Kow, Ronald L Klein, Patricia Szot, Linda Robinson, Chris Guthrie, Aleen Saxton, Nicholas M Kanaan, Murray A Raskind, Elaine R Peskind, John Q Trojanowski, Virginia M Y Lee, Li-San Wang, C Dirk Keene, Thomas Bird, Gerard D Schellenberg, Brian C Kraemer
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science translational medicine 11 (523) (2020)
Mamatha Damodarasamy, Robert B Vernon, Jasmine L Pathan, C Dirk Keene, Anthony J Day, William A Banks, May J Reed
The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA). Fluids and barriers of the CNS 17 (1) (2020)
Zsolt Bagi, Dieter D Brandner, Phuong Le, David W McNeal, Xi Gong, Huijuan Dou, David J Fulton, Allison Beller, Thuan Ngyuen, Eric B Larson, Thomas J Montine, C Dirk Keene, Stephen A Back
Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter. Annals of neurology 83 (1) (2019)
Ralph B Puchalski, Nameeta Shah, Jeremy Miller, Rachel Dalley, Steve R Nomura, Jae-Guen Yoon, Kimberly A Smith, Michael Lankerovich, Darren Bertagnolli, Kris Bickley, Andrew F Boe, Krissy Brouner, Stephanie Butler, Shiella Caldejon, Mike Chapin, Suvro Datta, Nick Dee, Tsega Desta, Tim Dolbeare, Nadezhda I Dotson, Amanda Ebbert, David Feng, Xu Feng, Michael Fisher, Garrett Gee, Jeff Goldy, Lindsey Gourley, Benjamin W Gregor, Guangyu Gu, Nika Hejazinia, John Hohmann, Parvinder Hothi, Robert Howard, Kevin Joines, Ali Kriedberg, Leonard Kuan, Chris Lau, Felix Lee, Hwahyung Lee, Tracy Lemon, Fuhui Long, Naveed Mastan, Erika Mott, Chantal Murthy, Kiet Ngo, Eric Olson, Melissa Reding, Zack Riley, David Rosen, David Sandman, Nadiya V Shapovalova, Clifford R Slaughterbeck, Andrew Sodt, Graham Stockdale, Aaron Szafer, Wayne Wakeman, Paul E Wohnoutka, Steven J White, Don Marsh, Robert C Rostomily, Lydia Ng, Chinh Dang, Allan Jones, Bart Keogh, Haley R Gittleman, Jill S Barnholtz-Sloan, Patrick J Cimino, Megha S Uppin, C Dirk Keene, Farrokh R Farrokhi, Justin D Lathia, Michael E Berens, Antonio Iavarone, Amy Bernard, Ed S Lein, John W Phillips, Steven W Rostad, Charles Cobbs, Michael J Hawrylycz, Greg D Foltz
An anatomic transcriptional atlas of human glioblastoma. Science (New York, N.Y.) 360 (6389) (2018)
Jeremy A Miller, Angela Guillozet-Bongaarts, Laura E Gibbons, Nadia Postupna, Anne Renz, Allison E Beller, Susan M Sunkin, Lydia Ng, Shannon E Rose, Kimberly A Smith, Aaron Szafer, Chris Barber, Darren Bertagnolli, Kristopher Bickley, Krissy Brouner, Shiella Caldejon, Mike Chapin, Mindy L Chua, Natalie M Coleman, Eiron Cudaback, Christine Cuhaciyan, Rachel A Dalley, Nick Dee, Tsega Desta, Tim A Dolbeare, Nadezhda I Dotson, Michael Fisher, Nathalie Gaudreault, Garrett Gee, Terri L Gilbert, Jeff Goldy, Fiona Griffin, Caroline Habel, Zeb Haradon, Nika Hejazinia, Leanne L Hellstern, Steve Horvath, Kim Howard, Robert Howard, Justin Johal, Nikolas L Jorstad, Samuel R Josephsen, Chihchau L Kuan, Florence Lai, Eric Kenji Lee, Felix Lee, Tracy Lemon, Xianwu Li, Desiree A Marshall, Jose Melchor, Shubhabrata Mukherjee, Julie Nyhus, Julie Pendergraft, Lydia Potekhina, Elizabeth Y Rha, Samantha Rice, David Rosen, Abharika Sapru, Aimee Schantz, Elaine Shen, Emily Sherfield, Shu Shi, Andy J Sodt, Nivretta Thatra, Michael Tieu, Angela M Wilson, Thomas J Montine, Eric B Larson, Amy Bernard, Paul K Crane, Richard G Ellenbogen, C Dirk Keene, Ed S Lein
Neuropathological and transcriptomic characteristics of the aged brain. eLife 6 (2017)
Rajnish Bharadwaj, Patrick J Cimino, Margaret E Flanagan, Caitlin S Latimer, Luis F Gonzalez-Cuyar, Gordana Juric-Sekhar, Thomas J Montine, Desiree A Marshall, C Dirk Keene
Application of the condensed protocol for the NIA-AA guidelines for the neuropathological assessment of Alzheimer's disease in an academic clinical practice. Histopathology 72 (3) (2017)

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C Dirk Keene (C Keene)