Login / Signup

Scleroderma renal crisis triggered by ibuprofen: Insights on complement-directed therapy.

Prochore Kamgang SemeuMaxime TaghaviCaroline GeersLuc MouthonLeonel Barreto GutierrezPatrick Stordeur
Published in: Journal of scleroderma and related disorders (2023)
Scleroderma renal crisis is a severe complication of systemic sclerosis with a poor prognosis. Therefore, identifying precipitating factors is essential. Among known risk factors, only few are reversible. On the contrary, anti-C5 therapy appears effective, at least in some cases. We describe a 59-year-old man with diffuse cutaneous systemic sclerosis who developed life-threatening scleroderma renal crisis following ibuprofen administration. Despite aggressive management, he did not improve. Renal biopsy have displayed features of thrombotic microangiopathy but no complement deposition. We then discuss the pathomechanism of scleroderma renal crisis that could drive eculizumab treatment since some renal biopsies exhibit complement deposits and others do not.
Keyphrases
  • systemic sclerosis
  • interstitial lung disease
  • poor prognosis
  • public health
  • risk factors
  • long non coding rna
  • rheumatoid arthritis
  • mesenchymal stem cells
  • low grade
  • idiopathic pulmonary fibrosis
  • drug induced