Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice.
Xiaoying LiuGrace L GuoBo KongDavid B HilburnSusan C HubchakSeong ParkBrian LeCuyerAntony HsiehLi WangDeyu FangRichard M GreenPublished in: Hepatology (Baltimore, Md.) (2018)
FXR signaling activates the IRE1α/XBP1 pathway in vivo and in vitro. FXR pathway activation increases XBP1 splicing and enhances p-IRE1α expression. These effects are mediated, at least in part, by SHP. IRE1α/XBP1 pathway activation by bile acids and pharmacological FXR agonists may be protective during liver injury and may have therapeutic implications for liver diseases. (Hepatology 2018;68:304-316).