Results of a randomized phase III/IV trial comparing intermittent bolus versus continuous infusion of antihaemophilic factor (recombinant) in adults with severe or moderately severe haemophilia A undergoing major orthopaedic surgery.

Ingrid Pabinger-FaschingVasily MamonovJerzy WindygaWerner EnglJennifer DoraltSrilatha TangadaGerald SpottsBruce Ewenstein

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2021)

CI administration of antihaemophilic factor (recombinant) is a viable alternative to BI in patients with haemophilia A undergoing major orthopaedic surgery, providing comparable efficacy and safety.

Keyphrases

phase iii
minimally invasive
open label
coronary artery bypass
clinical trial
phase ii
double blind
early onset
surgical site infection
placebo controlled
low dose
study protocol
high intensity
cell free
coronary artery disease
randomized controlled trial
atrial fibrillation